Title | A call for transparent reporting to optimize the predictive value of preclinical research. |
Publication Type | Journal Article |
Year of Publication | 2012 |
Authors | Landis SC, Amara SG, Asadullah K, Austin CP, Blumenstein R, Bradley EW, Crystal RG, Darnell RB, Ferrante RJ, Fillit H, Finkelstein R, Fisher M, Gendelman HE, Golub RM, Goudreau JL, Gross RA, Gubitz AK, Hesterlee SE, Howells DW, Huguenard J, Kelner K, Koroshetz W, Krainc D, Lazic SE, Levine MS, Macleod MR, McCall JM, Moxley RT, Narasimhan K, Noble LJ, Perrin S, Porter JD, Steward O, Unger E, Utz U, Silberberg SD |
Journal | Nature |
Volume | 490 |
Issue | 7419 |
Pagination | 187-91 |
Date Published | 2012 Oct 11 |
ISSN | 1476-4687 |
Keywords | Animals, Publishing, Random Allocation, Research Design, Sample Size, Statistics as Topic |
Abstract | The US National Institute of Neurological Disorders and Stroke convened major stakeholders in June 2012 to discuss how to improve the methodological reporting of animal studies in grant applications and publications. The main workshop recommendation is that at a minimum studies should report on sample-size estimation, whether and how animals were randomized, whether investigators were blind to the treatment, and the handling of data. We recognize that achieving a meaningful improvement in the quality of reporting will require a concerted effort by investigators, reviewers, funding agencies and journal editors. Requiring better reporting of animal studies will raise awareness of the importance of rigorous study design to accelerate scientific progress. |
DOI | 10.1038/nature11556 |
Alternate Journal | Nature |
PubMed ID | 23060188 |
PubMed Central ID | PMC3511845 |
Grant List | R01 NS041574 / NS / NINDS NIH HHS / United States P30 MH062261 / MH / NIMH NIH HHS / United States T32 MH020016 / MH / NIMH NIH HHS / United States R01 NS034774 / NS / NINDS NIH HHS / United States P01 NS012151 / NS / NINDS NIH HHS / United States T32 NS007280 / NS / NINDS NIH HHS / United States UL1 RR024160 / RR / NCRR NIH HHS / United States R01 NS006477 / NS / NINDS NIH HHS / United States Z99 NS999999 / / Intramural NIH HHS / United States |