Effects of Music and White Noise Exposure on the Gut Microbiota, Oxidative Stress, and Immune-Related Gene Expression of Mice.

TitleEffects of Music and White Noise Exposure on the Gut Microbiota, Oxidative Stress, and Immune-Related Gene Expression of Mice.
Publication TypeJournal Article
Year of Publication2023
AuthorsZhang Z, Wu Y, Zhou S, Fu P, Yan H
JournalMicroorganisms
Volume11
Issue9
Date Published2023 Sep 10
ISSN2076-2607
Abstract

The microbiota in gastrointestinal tracts is recognized to play a pivotal role in the health of their hosts. Music and noise are prevalent environmental factors in human society and animal production and are reported to impact their welfare and physiological conditions; however, the information on the relationship between the microbiota, physiological status, and sound is limited. This study investigated the impact of music and white noise exposure in mice through 16s rRNA gene sequencing, enzyme assay, and qPCR. The results demonstrate that white noise induced oxidative stress in animals by decreasing serum SOD and GSH-PX activity while increasing LDH activity and MDA levels ( < 0.05). Conversely, no oxidative stress was observed in the music treatment group. The relative gene expression of IFN-γ and IL-1β decreased in the white noise group compared to the music and control groups. The 16s rRNA gene amplicon sequencing revealed that , , , and were dominant among all the groups. Furthermore, the proportion of increased in the music treatment group but decreased in the white noise treatment group compared to the control group. In conclusion, white noise has detrimental impacts on the gut microbiota, antioxidant activity, and immunity of mice, while music is potentially beneficial.

DOI10.3390/microorganisms11092272
Alternate JournalMicroorganisms
PubMed ID37764116
PubMed Central IDPMC10536120
Grant ListZDYF2019031 / / Finance Science and Technology project of Hainan Province /
KYQD_ZR2017212 / / Research Start-Up Funds from Hainan University in China /