Effects of music intervention on inflammatory markers in critically ill and post-operative patients: A systematic review of the literature.

TitleEffects of music intervention on inflammatory markers in critically ill and post-operative patients: A systematic review of the literature.
Publication TypeJournal Article
Year of Publication2018
AuthorsKhan SH, Kitsis M, Golovyan D, Wang S, Chlan LL, Boustani M, Khan BA
JournalHeart Lung
Volume47
Issue5
Pagination489-496
Date Published2018 Sep - Oct
ISSN1527-3288
KeywordsBiomarkers, Critical Illness, Female, Humans, Inflammation, Intensive Care Units, Male, Music Therapy, Postoperative Period, Stress, Physiological
Abstract

BACKGROUND: Music listening has been shown to reduce anxiety, stress, and patient tolerance of procedures. Music may also have beneficial effects on inflammatory biomarkers in intensive care and post-operative patients, but the quality of evidence is not clear.

OBJECTIVES: We conducted a systematic review to evaluate the effects of music on inflammatory biomarkers in intensive care, and post-operative patients.

METHODS: A comprehensive search of the literature was performed. After screening 1570 references, full text review of 26 studies was performed. Fourteen studies were selected for inclusion.

RESULTS: Seven studies showed a significant decrease in cortisol levels, but the level of evidence was low. Three studies had low risk of methodological bias, while 11 studies had high risk of bias.

CONCLUSIONS: Music intervention may decrease cortisol levels, but other biomarkers remain unchanged. Given the low level of evidence, further research on music effects on inflammatory biomarkers is needed.
DOI10.1016/j.hrtlng.2018.05.015
Alternate JournalHeart Lung
PubMed ID30001799
PubMed Central IDPMC6380515
Grant ListR01 HL131730 / HL / NHLBI NIH HHS / United States
T32 HL091816 / HL / NHLBI NIH HHS / United States