Title | Integrating music-based interventions with Gamma-frequency stimulation: Implications for healthy ageing. |
Publication Type | Journal Article |
Year of Publication | 2022 |
Authors | Tichko P, Kim JChul, Large E, Loui P |
Journal | Eur J Neurosci |
Volume | 55 |
Issue | 11-12 |
Pagination | 3303-3323 |
Date Published | 2022 Jun |
ISSN | 1460-9568 |
Keywords | Alzheimer Disease, Animals, Brain, Cognitive Dysfunction, Healthy Aging, Music |
Abstract | In recent years, music-based interventions (MBIs) have risen in popularity as a non-invasive, sustainable form of care for treating dementia-related disorders, such as Mild Cognitive Impairment (MCI) and Alzheimer's disease (AD). Despite their clinical potential, evidence regarding the efficacy of MBIs on patient outcomes is mixed. Recently, a line of related research has begun to investigate the clinical impact of non-invasive Gamma-frequency (e.g., 40 Hz) sensory stimulation on dementia. Current work, using non-human-animal models of AD, suggests that non-invasive Gamma-frequency stimulation can remediate multiple pathophysiologies of dementia at the molecular, cellular and neural-systems scales, and, importantly, improve cognitive functioning. These findings suggest that the efficacy of MBIs could, in theory, be enhanced by incorporating Gamma-frequency stimulation into current MBI protocols. In the current review, we propose a novel clinical framework for non-invasively treating dementia-related disorders that combines previous MBIs with current approaches employing Gamma-frequency sensory stimulation. We theorize that combining MBIs with Gamma-frequency stimulation could increase the therapeutic power of MBIs by simultaneously targeting multiple biomarkers of dementia, restoring neural activity that underlies learning and memory (e.g., Gamma-frequency neural activity, Theta-Gamma coupling), and actively engaging auditory and reward networks in the brain to promote behavioural change. |
DOI | 10.1111/ejn.15059 |
Alternate Journal | Eur J Neurosci |
PubMed ID | 33236353 |
PubMed Central ID | PMC9899516 |
Grant List | R01 AG078376 / AG / NIA NIH HHS / United States R21 AG075232 / AG / NIA NIH HHS / United States R43 AG078012 / AG / NIA NIH HHS / United States |